Magnesium zinc oxide nanostructure modified biosensor and monitoring of response of cell population to an agent using the same

• Main Authors: Reyes, Pavel I, Zheng, Steven, Zheng, Andrew, Yang, Keyang, Lu, Yicheng
• Format: Patent
• Language: English
• Published: 13.10.2020
• Subjects: APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ELECTRICITY; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OF MECHANICAL VIBRATIONS OR ULTRASONIC, SONIC ORINFRASONIC WAVES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; NANOTECHNOLOGY; PERFORMING OPERATIONS; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; SPIRITS; TESTING; TRANSPORTING; VINEGAR; WEIGHING; WINE

A magnesium zinc oxide (MZO) nanostructure modified quartz crystal microbalance (MZOnano-QCM) takes advantage of the unique sensing ability and biocompatibility of MZO-based nanostructures, and combines them with the dynamic impedance spectrum capability of the bulk acoustic wave (BAW) devices including QCM, to form a real-time, noninvasive and label-free cell monitoring biosensor, specifically detecting the susceptibility and resistance of bacterial and fungal strains and cancer cells to various antibiotic and antifungal drugs and anticancer drugs, respectively.