5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5-azaspiro[2.5]octane-8-carboxylic acid derivatives as novel JAK kinase inhibitors

• Main Authors: Larsen, Mogens, Greve, Daniel Rodriguez, Nørremark, Bjarne, Ritzen, Andreas
• Format: Patent
• Language: English
• Published: 13.10.2020
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

wherein X represents NH or 0; n is an integer selected from 1-3; Y represents a bond, -C(O)O-*, -C(O)OR3-* or -C(O)NHR3-*; W is selected from the group consisting of phenyl, pyridyl, (C3-C7)cycloalkyl and 4-6 membered heterocycloalkyl; or pharmaceutically acceptable salts, hydrates, or solvates ther...