5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-5-azaspiro[2.5]octane-8-carboxylic acid derivatives as novel JAK kinase inhibitors

wherein X represents NH or 0; n is an integer selected from 1-3; Y represents a bond, -C(O)O-*, -C(O)OR3-* or -C(O)NHR3-*; W is selected from the group consisting of phenyl, pyridyl, (C3-C7)cycloalkyl and 4-6 membered heterocycloalkyl; or pharmaceutically acceptable salts, hydrates, or solvates ther...

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Bibliographic Details
Main Authors Larsen, Mogens, Greve, Daniel Rodriguez, Nørremark, Bjarne, Ritzen, Andreas
Format Patent
LanguageEnglish
Published 13.10.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:wherein X represents NH or 0; n is an integer selected from 1-3; Y represents a bond, -C(O)O-*, -C(O)OR3-* or -C(O)NHR3-*; W is selected from the group consisting of phenyl, pyridyl, (C3-C7)cycloalkyl and 4-6 membered heterocycloalkyl; or pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention relates further to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.
Bibliography:Application Number: US201816483079