Boron compounds as inhibitors of lipoxygenase and the lipoxygenase pathway, and preparation and use thereof

The invention relates to chemical compounds of the general structure [A - R3 - X - R4] where A = [R1 - R2] or [R1] R1 = aryl, heteroaryl R2 = alkyl, aryl, heteroaryl, carbonyl, thiocarbonyl, alkyl ester, alkyl thioester R3 = O, S, NH X = closo- or nido-boron cluster R4 = formula (I) where Z = OH, SH...

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Bibliographic Details
Main Authors Hey-Hawkins, Evamarie, Kuhnert, Robert
Format Patent
LanguageEnglish
Published 15.09.2020
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to chemical compounds of the general structure [A - R3 - X - R4] where A = [R1 - R2] or [R1] R1 = aryl, heteroaryl R2 = alkyl, aryl, heteroaryl, carbonyl, thiocarbonyl, alkyl ester, alkyl thioester R3 = O, S, NH X = closo- or nido-boron cluster R4 = formula (I) where Z = OH, SH, NH2 where R5 is selected from H, alkyl, aryl, heteroaryl, alkyl ether, alkyl thioether, alkylamine and R6 is selected from alkyl, aryl, heteroaryl, alkyl ether, alkyl thioether, alkylamine and where R3 and R4 are in meta or para positions to one another, to a process for preparation thereof and to the use thereof, especially in medicine, for example in the inhibition of lipoxygenase.
Bibliography:Application Number: US201615770477