Cell therapy with polarized macrophages for tissue regeneration

The invention provides an in vitro method for inducing macrophage polarization to an M2 phenotype. The method comprises the in vitro exposure of macrophages to repeated series of hypoxia-reoxygenation. Activated M2 macrophages obtained by this method overexpress molecules important for tissue remode...

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Main Authors García De La Riva Mestre, Pablo, Hotter Corripio, María Georgina, Sánchez Moreno, Jaime, Martín Cordero, Jorge Vicente, Domínguez Sánchez, Rubén, Ginesta Buch, Xavier, Rodríguez García, Anna, Sola Martínez, Ana Maria, Castillo García, Adrián
Format Patent
LanguageEnglish
Published 28.07.2020
Subjects
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The invention provides an in vitro method for inducing macrophage polarization to an M2 phenotype. The method comprises the in vitro exposure of macrophages to repeated series of hypoxia-reoxygenation. Activated M2 macrophages obtained by this method overexpress molecules important for tissue remodeling and amelioration of inflammation, thus they are useful as cell therapy for tissue regeneration. The invention also provides pharmaceutical compositions and kits comprising the M2 macrophages obtained by the method, as well as a device for inducing hypoxia and re-oxygenation conditions on isolated macrophages according to the method.
Bibliography:Application Number: US201715715036