Process for preparing and purifying the LFA-1 antagonist lifitegrast
The invention relates to a process for the purification of lifitegrast (I) by i) reacting lifitegrast (I) with dicyclohexylamine to give the dicyclohexylamine salt of lifitegrast (la); ii) isolating the salt (Ia) from the reaction medium; iii) converting the isolated salt (Ia) into lifitegrast (I) b...
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| Main Authors | , |
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| Format | Patent |
| Language | English |
| Published |
28.07.2020
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The invention relates to a process for the purification of lifitegrast (I) by i) reacting lifitegrast (I) with dicyclohexylamine to give the dicyclohexylamine salt of lifitegrast (la); ii) isolating the salt (Ia) from the reaction medium; iii) converting the isolated salt (Ia) into lifitegrast (I) by treatment with an acid; and iv) isolating lifitegrast (I) from the reaction medium. It also relates to the dicyclohexylamine salt of lifitegrast (Ia) and to a process for its preparation. |
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| AbstractList | The invention relates to a process for the purification of lifitegrast (I) by i) reacting lifitegrast (I) with dicyclohexylamine to give the dicyclohexylamine salt of lifitegrast (la); ii) isolating the salt (Ia) from the reaction medium; iii) converting the isolated salt (Ia) into lifitegrast (I) by treatment with an acid; and iv) isolating lifitegrast (I) from the reaction medium. It also relates to the dicyclohexylamine salt of lifitegrast (Ia) and to a process for its preparation. |
| Author | Marquillas Olondriz, Francisco Berzosa Rodríguez, Xavier |
| Author_xml | – fullname: Berzosa Rodríguez, Xavier – fullname: Marquillas Olondriz, Francisco |
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| Snippet | The invention relates to a process for the purification of lifitegrast (I) by i) reacting lifitegrast (I) with dicyclohexylamine to give the dicyclohexylamine... |
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| Title | Process for preparing and purifying the LFA-1 antagonist lifitegrast |
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