Process for preparing and purifying the LFA-1 antagonist lifitegrast
The invention relates to a process for the purification of lifitegrast (I) by i) reacting lifitegrast (I) with dicyclohexylamine to give the dicyclohexylamine salt of lifitegrast (la); ii) isolating the salt (Ia) from the reaction medium; iii) converting the isolated salt (Ia) into lifitegrast (I) b...
Saved in:
Main Authors | , |
---|---|
Format | Patent |
Language | English |
Published |
28.07.2020
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The invention relates to a process for the purification of lifitegrast (I) by i) reacting lifitegrast (I) with dicyclohexylamine to give the dicyclohexylamine salt of lifitegrast (la); ii) isolating the salt (Ia) from the reaction medium; iii) converting the isolated salt (Ia) into lifitegrast (I) by treatment with an acid; and iv) isolating lifitegrast (I) from the reaction medium. It also relates to the dicyclohexylamine salt of lifitegrast (Ia) and to a process for its preparation. |
---|---|
Bibliography: | Application Number: US201816632057 |