PH-sensitive linkers for delivering a therapeutic agent

The invention provides a pH-sensitive linker that can simultaneously bind metallic nanoparticles and one or more agents with various molecular size. The linker of the invention can deliver the agents into cells involved in disease processes or close to cells so that the agents can selectively target...

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Bibliographic Details
Main Authors Huang, Wei-Jan, Lin, Huan-Yu, Lin, Ching-Yi, Tsai, Meng-Ju, Chao, Ye-Su, Chi, Li-Ling, Wu, Yi-Hong, Chen, Chia-Nan, Liao, Yu-Jung, Hsu, Wan-Yi
Format Patent
LanguageEnglish
Published 23.06.2020
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides a pH-sensitive linker that can simultaneously bind metallic nanoparticles and one or more agents with various molecular size. The linker of the invention can deliver the agents into cells involved in disease processes or close to cells so that the agents can selectively target and effect on the cells. The target delivery provided by the linker of the invention can be used for example for disease sensing, imaging, drug delivery, and therapy.
Bibliography:Application Number: US201615746544