5-substituted indazole-3-carboxamides and preparation and use thereof

Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellul...

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Main Authors Wallace, David Mark, Hofilena, Brian Joseph, Hood, John, Kumar KC, Sunil, Bollu, Venkataiah, Mittapalli, Gopi Kumar, Eastman, Brian, Mak, Chi Ching
Format Patent
LanguageEnglish
Published 02.06.2020
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Summary:Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, fibrotic disorders, cartilage (chondral) defects, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, and neurological conditions/disorders/diseases linked to overexpression of DYRK1A.
Bibliography:Application Number: US201715653747