Therapeutic nanoparticles comprising a protonatable nitrogen therapeutic agent and methods of making and using same

• Main Authors: Figueiredo, Maria, Van Geen Hoven, Christina, Song, Yong-ho, Troiano, Greg, Dewitt, David, Peeke, Erick, Wang, Hong, Wright, James
• Format: Patent
• Language: English
• Published: 10.03.2020
• Subjects: HUMAN NECESSITIES; HYGIENE; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEDICAL OR VETERINARY SCIENCE; NANOTECHNOLOGY; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; TRANSPORTING

The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid, a basic therapeutic agent having a protonatable nitrogen, and a polymer. Other aspects include methods of making and using such nanoparticles.