Mikto-arm star polymers for delivery of therapeutic agents

Mikto-arm star polymers were prepared comprising non-charged hydrophilic poly(ethylene oxide) arms and hydrophobic arms comprising a poly(propylene oxide) chain or phytol group. The polymer arms are covalently linked to a hydrophobic crosslinked polyester core formed by ring opening polymerization o...

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Bibliographic Details
Main Authors Nor, Siti Mariam B. Mohd, Malek, Emilia B. A, Badri, Khairiah H, Piunova, Victoria A
Format Patent
LanguageEnglish
Published 26.11.2019
Subjects
CHEMISTRY
COMPOSITIONS BASED THEREON
HUMAN NECESSITIES
HYGIENE
MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Summary:Mikto-arm star polymers were prepared comprising non-charged hydrophilic poly(ethylene oxide) arms and hydrophobic arms comprising a poly(propylene oxide) chain or phytol group. The polymer arms are covalently linked to a hydrophobic crosslinked polyester core formed by ring opening polymerization of a bis-cyclic ester initiated by mono-nucleophilic polymer arm precursors. The mikto-arm star polymers show improved loading capacity for Coenzyme Q10 (CoQ10).
Bibliography:Application Number: US201715713971