Substituted tetrahydropyrans as CCR2 modulators

Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (Ia1′):and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of CCR2 receptors.

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Bibliographic Details
Main Authors Fan, Junfa, Lui, Rebecca M, Zhang, Penglie, McMahon, Jeffrey P, Zeng, Yibin, Powers, Jay P, Kalisiak, Jaroslaw, Mali, Venkat Reddy, Tanaka, Hiroko
Format Patent
LanguageEnglish
Published 05.11.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds are provided that are modulators of the CCR2 receptor. The compounds have the general formula (Ia1′):and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of CCR2 receptors.
Bibliography:Application Number: US201715692811