Immunomodulators

The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.

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Bibliographic Details
Main Authors Scola, Paul Michael, Sun, Li-Qiang, Zhao, Qian, Mull, Eric, Allen, Martin Patrick, Li, Ling, Mapelli, Claudio, Poirier, Maude A, Miller, Michael Matthew, Gillis, Eric P
Format Patent
LanguageEnglish
Published 22.10.2019
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
Bibliography:Application Number: US201715465218