Notch pathway signaling inhibitor compounds

The present invention provides the following compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing said compounds useful as a Notch pathway signaling inhibitor for the treatment of named cancers, sensorineural hearing loss caused by auditory hair cell lo...

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Main Authors Gill, John C, Van Es, Helmuth Hendrikus Gerardus, Edge, Albert, Zhao, Gaiying, Hipskind, Philip Arthur, Wrobleski, Aaron D, Clay, Julia Marie, Patel, Bharvin Kumar
Format Patent
LanguageEnglish
Published 22.10.2019
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides the following compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing said compounds useful as a Notch pathway signaling inhibitor for the treatment of named cancers, sensorineural hearing loss caused by auditory hair cell loss, and inducing auditory hair cell generation.
Bibliography:Application Number: US201615736345