Methods of treatment using antisense oligomers and conjugates targeting PCSK9
The present invention relates to oligomeric compounds and conjugates thereof that target Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) PCSK9 mRNA in a cell, leading to reduced expression of PCSK9. Reduction of PCSK9 expression is beneficial for a range of medical disorders, such as hyperchol...
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Main Authors | , , , , , |
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Format | Patent |
Language | English |
Published |
20.08.2019
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to oligomeric compounds and conjugates thereof that target Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) PCSK9 mRNA in a cell, leading to reduced expression of PCSK9. Reduction of PCSK9 expression is beneficial for a range of medical disorders, such as hypercholesterolemia and related disorders. |
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Bibliography: | Application Number: US201815971970 |