Method for making a biofabricated material containing collagen fibrils

• Main Authors: Williamson, David Thomas, Purcell, Brendan Patrick, Schofer, Susan J, Spinella, Stephen M, Congdon, Amy, Marga, Francoise Suzanne, Cassingham, Darryl Miles
• Format: Patent
• Language: English
• Published: 06.08.2019
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBONFILAMENTS; APPARATUS THEREFOR; BRAIDING; CARBONISING RAGS TO RECOVER ANIMAL FIBRES; CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS,THREADS, FIBRES, BRISTLES OR RIBBONS; CHEMICAL TREATMENT OF HIDES, SKINS OR LEATHER, e.g. TANNING,IMPREGNATING, FINISHING; CHEMICAL TREATMENT OF NATURAL FILAMENTARY OR FIBROUS MATERIALTO OBTAIN FILAMENTS OR FIBRES FOR SPINNING; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS FOR TANNING; COTTON-WOOL; DYEING LEATHER, FURS, OR SOLID MACROMOLECULAR SUBSTANCES INANY FORM; DYEING OR PRINTING TEXTILES; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS,NON-WOVEN FABRICS; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR; FLEXIBLE SHEET MATERIAL NOT OTHERWISE PROVIDED FOR; GENERAL PROCESSES OF COMPOUNDING; HIDES; KNITTING; LACE-MAKING; LAUNDERING; LAYERED PRODUCTS; LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT ORNON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM; LEATHER; MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARYMATERIAL; METALLURGY; NATURAL OR ARTIFICIAL THREADS OR FIBRES; NON-WOVEN FABRICS; ORGANIC CHEMISTRY; ORGANIC MACROMOLECULAR COMPOUNDS; PELTS; PEPTIDES; PERFORMING OPERATIONS; SKINS; SPINNING; TEXTILES; THEIR PREPARATION OR CHEMICAL WORKING-UP; TRANSPORTING; TREATMENT OF TEXTILES OR THE LIKE; TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS,FABRICS, FEATHERS, OR FIBROUS GOODS MADE FROM SUCH MATERIALS; TRIMMINGS; WADDING; WALL, FLOOR OR LIKE COVERING MATERIALS, e.g. LINOLEUM,OILCLOTH, ARTIFICIAL LEATHER, ROOFING FELT, CONSISTING OF AFIBROUS WEB COATED WITH A LAYER OF MACROMOLECULARMATERIAL; WORKING-UP

Described herein is a method for producing a biofabricated material from collagen or collagen-like proteins which are recombinantly produced and which contain substantially no 3-hydroxyproline. The collagen or collagen-like proteins are isolated from animal sources, or produced by recombinant DNA techniques or by chemical synthesis. The collagen or collagen-like proteins are fibrillated, crosslinked, dehydrated and lubricated thus forming the biofabricated material having a substantially uniform network of collagen fibrils.