Pyridone and aza-pyridone compounds and methods of use

Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I f...

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Bibliographic Details
Main Authors Barbosa, Antonio J. M, Schmitt, Aaron C, Zhao, Zhongdong, Kropf, Jeffrey E, Young, Wendy, Zhang, Honglu, Blomgren, Peter A, Mitchell, Scott A, Lee, Seung H, Xu, Jianjun, Krishnamoorthy, Ravi, Wang, Xiaojing, Currie, Kevin S, Ortwine, Daniel, Zhichkin, Pavel E
Format Patent
LanguageEnglish
Published 09.07.2019
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Pyridone and aza-pyridone compounds of Formula I are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
Bibliography:Application Number: US201815905363