Mutant OPAA enzyme with increased catalytic efficiency on organophosphorus compound GP
The invention is directed toward mutant, non-wild-type organophosphorus acid anhydrolase enzymes having three site mutations, methods of production, and methods of use to effectively degrade toxic organophosphorus compounds, most preferably GP (2,2′-dimethylcyclopentyl methylphosphonofluoridate).
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| Main Authors | , , , |
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| Format | Patent |
| Language | English |
| Published |
02.07.2019
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The invention is directed toward mutant, non-wild-type organophosphorus acid anhydrolase enzymes having three site mutations, methods of production, and methods of use to effectively degrade toxic organophosphorus compounds, most preferably GP (2,2′-dimethylcyclopentyl methylphosphonofluoridate). |
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| AbstractList | The invention is directed toward mutant, non-wild-type organophosphorus acid anhydrolase enzymes having three site mutations, methods of production, and methods of use to effectively degrade toxic organophosphorus compounds, most preferably GP (2,2′-dimethylcyclopentyl methylphosphonofluoridate). |
| Author | Harvey, Steven P Dixon, Melissa M McMahon, Leslie R Guelta, Mark A |
| Author_xml | – fullname: McMahon, Leslie R – fullname: Harvey, Steven P – fullname: Guelta, Mark A – fullname: Dixon, Melissa M |
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| Notes | Application Number: US201815880747 |
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| RelatedCompanies | The United States of America as Represented by the Secretary of the Army U.S. Army Edgewood Chemical Biological Center |
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| Snippet | The invention is directed toward mutant, non-wild-type organophosphorus acid anhydrolase enzymes having three site mutations, methods of production, and... |
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| SubjectTerms | BEER BIOCHEMISTRY CHEMICAL MATERIALS FOR USE IN BREATHING APPARATUS CHEMICAL MEANS FOR EXTINGUISHING FIRES OR FOR COMBATING ORPROTECTING AGAINST HARMFUL CHEMICAL AGENTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FIRE-FIGHTING HUMAN NECESSITIES HYGIENE LIFE-SAVING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| Title | Mutant OPAA enzyme with increased catalytic efficiency on organophosphorus compound GP |
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