Mutant OPAA enzyme with increased catalytic efficiency on organophosphorus compound GP

The invention is directed toward mutant, non-wild-type organophosphorus acid anhydrolase enzymes having three site mutations, methods of production, and methods of use to effectively degrade toxic organophosphorus compounds, most preferably GP (2,2′-dimethylcyclopentyl methylphosphonofluoridate).

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Bibliographic Details
Main Authors McMahon, Leslie R, Harvey, Steven P, Guelta, Mark A, Dixon, Melissa M
Format Patent
LanguageEnglish
Published 02.07.2019
Subjects
BEER
BIOCHEMISTRY
CHEMICAL MATERIALS FOR USE IN BREATHING APPARATUS
CHEMICAL MEANS FOR EXTINGUISHING FIRES OR FOR COMBATING ORPROTECTING AGAINST HARMFUL CHEMICAL AGENTS
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FIRE-FIGHTING
HUMAN NECESSITIES
HYGIENE
LIFE-SAVING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:The invention is directed toward mutant, non-wild-type organophosphorus acid anhydrolase enzymes having three site mutations, methods of production, and methods of use to effectively degrade toxic organophosphorus compounds, most preferably GP (2,2′-dimethylcyclopentyl methylphosphonofluoridate).
Bibliography:Application Number: US201815880747