Compositions with a rheological modifier to reduce dissolution variability

The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time de...

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Bibliographic Details
Main Authors Chao, Wendy, Su, Huey-Ching, Shanker, Ravi M, Yum, Su Il, Zamloot, Michael S, Bratin, Karl, Fu, Roger
Format Patent
LanguageEnglish
Published 28.05.2019
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present disclosure provides compositions (e.g., extended release compositions) which exhibit a desirable pharmacokinetic profile of an active agent while providing reduced dissolution sample variability, e.g., in the form of reduced inter-capsule variability and/or a reduction in storage-time dependent change in mean release of the active agent from the composition. Related methods of making and administering the disclosed compositions are also provided.
Bibliography:Application Number: US201715826226