3′end caps for RNAi agents for use in RNA interference

The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3′ end cap. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.

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Bibliographic Details
Main Authors Gossert, Alvar, Geno, Erin, Greenidge, Paulette, Fernandez, Cesar, Patnaik, Anup, Rondeau, Jean-Michel Rene, Blommers, Marcel, Natt, Francois Jean-Charles, Patterson, Andrew, Baryza, Jeremy Lee, Huesken, Dieter, Hunziker, Juerg, Weiler, Jan, Zhu, Meicheng
Format Patent
LanguageEnglish
Published 12.03.2019
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
DERIVATIVES THEREOF
ENZYMOLOGY
HETEROCYCLIC COMPOUNDS
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
SUGARS
VINEGAR
WINE
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Summary:The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3′ end cap. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.
Bibliography:Application Number: US201415025779