Closed vial fill system for aseptic dispensing

• Main Authors: Gleeson, James B, Prescott, James Alan, Danhof, Scott Nicholas, Husnu, Mehmet, Eshima, Dennis, Alcaide, Derrick Michael, Hassenpflug, Eric Gustin
• Format: Patent
• Language: English
• Published: 12.03.2019
• Subjects: BABY COMFORTERS; CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES; CONVEYING; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; DEVICES FOR RECEIVING SPITTLE; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS; DIAGNOSIS; HANDLING THIN OR FILAMENTARY MATERIAL; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGINGARTICLES OR MATERIALS; MEDICAL OR VETERINARY SCIENCE; PACKING; PERFORMING OPERATIONS; STORING; SURGERY; TRANSPORTING; UNPACKING

A closed path vial fill system includes a bulk product vial, a peristaltic pump operated by a stepper motor, a dispensing manifold assembly to which may be coupled at least one final product vial, an optional quality check station, and an optional waste collection system. A concentration, activity, and volume (CAV) sensor may be incorporated into the system to receive a radiopharmaceutical product directly from a synthesizing unit. A control system may be integrated into the system to provide automated control of various aspects of the radiopharmaceutical dispensing process. The system is used to aseptically dispense finished radiopharmaceuticals into receiving vessels, such as a Quality Control vial, a sterility vial, and/or final product vials, while providing users an efficient means for removing and discarding contaminated disposable components.