Methods of preparing lyophilized spherical-shaped pellets of biological materials

Methods for preparing lyophilized pellets of biological materials are described. The pellets have a substantially spherical shape and are prepared by freezing droplets of a liquid composition of a desired biological material on a flat, solid surface, in particular, a surface that does not have any c...

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Main Authors Kriss, Jennifer, Barr, Colleen, Bhambhani, Akhilesh, Isopi, Lynne, Evans, Robert, Sinacola, Jessica, Krah, David
Format Patent
LanguageEnglish
Published 22.01.2019
Subjects
BLASTING
CHEMISTRY
DRYING
DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
HEATING
HUMAN NECESSITIES
HYGIENE
LIGHTING
MECHANICAL ENGINEERING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
WEAPONS
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Summary:Methods for preparing lyophilized pellets of biological materials are described. The pellets have a substantially spherical shape and are prepared by freezing droplets of a liquid composition of a desired biological material on a flat, solid surface, in particular, a surface that does not have any cavities, followed by lyophilizing the frozen droplets. These methods are useful for preparing lyophilized pellets having a high concentration of a desired biological material, in particular a therapeutic protein or vaccine, and which have a faster reconstitution time than lyophilized powder cakes prepared in vials.
Bibliography:Application Number: US201214355405