Low hygroscopic aripiprazole drug substance and processes for the preparation thereof

The present invention provides low hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the anhydrous aripiprazole crystals is stored for an extended period.

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Bibliographic Details
Main Authors Abe, Kaoru, Aoki, Satoshi, Ooi, Yoshihiro, Kawasaki, Junichi, Nishioka, Yoshihiro, Yabuuchi, Tsuyoshi, Kobayashi, Noriyuki, Fujimura, Tsutomu, Ishigami, Makoto, Tominaga, Michiaki, Utsumi, Naoto, Taniguchi, Youichi, Yamada, Shohei, Shinhama, Koichi, Fujimoto, Kiyoshi, Tomikawa, Kenji, Takahashi, Masanori, Bando, Takuji, Nakagawa, Tomonori
Format Patent
LanguageEnglish
Published 11.12.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SEPARATION
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TRANSPORTING
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Summary:The present invention provides low hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the anhydrous aripiprazole crystals is stored for an extended period.
Bibliography:Application Number: US201514624595