KRas G12C inhibitors

The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

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Bibliographic Details
Main Authors Burgess, Laurence E, Hicken, Erik James, Lee, Matthew Randolf, Blake, James F, Vigers, Guy P. A, Gaudino, John J, Hinklin, Ronald Jay, Fischer, John P, Marx, Matthew Arnold, Savechenkov, Pavel, Tang, Tony P, Mejia, Macedonio J, Rodriguez, Martha E, Christensen, James Gail, Chicarelli, Mark Joseph, Zecca, Henry J, Fell, Jay Bradford
Format Patent
LanguageEnglish
Published 13.11.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
Bibliography:Application Number: US201715814279