Process and intermediates for making tubulysin analogs

wherein n, R1, R2, and R3 are as defined in the specification. Compound B can be used to make tubulysin analogs that are, in turn, useful as anti-cancer agents, particularly when deployed in an antibody-drug conjugate.

Saved in:
Bibliographic Details
Main Authors Ortiz, Adrian, Zhu, Jason J, Zheng, Bin, Luzung, Michael R, Eastgate, Martin D, Schmidt, Michael Anthony, Guerrero, Carlos A
Format Patent
LanguageEnglish
Published 23.10.2018
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:wherein n, R1, R2, and R3 are as defined in the specification. Compound B can be used to make tubulysin analogs that are, in turn, useful as anti-cancer agents, particularly when deployed in an antibody-drug conjugate.
Bibliography:Application Number: US201715623570