BENZIMIDAZOLE DERIVATIVES USEFUL IN TREATMENT OF VANILLOID RECEPTOR TRPV1 RELATED DISORDERS

The claimed invention provides benzimidazole derivatives antagonists of VR1, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds of Formula I may be used in the treatment of osteoarthritis, chronic tendinitis, pelvic pain and periphera...

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Bibliographic Details
Main Authors BROWN WILLIAM, JOHNSTONE SHAWN, LABRECQUE, DENIS
Format Patent
LanguageEnglish
Russian
Ukrainian
Published 12.12.2011
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The claimed invention provides benzimidazole derivatives antagonists of VR1, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds of Formula I may be used in the treatment of osteoarthritis, chronic tendinitis, pelvic pain and peripheral neuropathy, gastroesophageal reflux disease, irritable bowel s ndrome and overactive bladder. Formula I.I Изобретение касается производных бензимидазола формулы I и их применение в лечении расстройств, связанных с рецептором TRPVL.I Винахід стосується похідних бензімідазолу формули І та їх застосування у лікуванні розладів, пов'язаних з рецептором TRPVL.I
Bibliography:Application Number: UAA200900383