Controlled-release oral formulation and preparation method thereof

An oral formulation is provided, which includes a first composition and a second composition. The first composition includes a xanthine derivative. The second composition includes a xanthine derivative and an enteric excipient. The xanthine derivative of the second composition releases less than 35%...

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Bibliographic Details
Main Authors LU, SHAO CHUAN, SU, YU DE, CHUANG, JWEY YUAN
Format Patent
LanguageChinese
English
Published 11.03.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:An oral formulation is provided, which includes a first composition and a second composition. The first composition includes a xanthine derivative. The second composition includes a xanthine derivative and an enteric excipient. The xanthine derivative of the second composition releases less than 35% by weight within 90 minutes from in vitro dissolution, and the xanthine derivative of the second composition releases more than 50% by weight within 3 hours from in vitro dissolution. As such, the first composition may be used as an immediate release layer, and the second composition may be used as a delayed release layer to achieve a bilayer controlled-release oral formulation.
Bibliography:Application Number: TW202110128023