Benzimidazole or azabenzimidazole-6-carboxylic acid compounds and applications thereof

Provided in the present invention are a benzimidazole or azabenzimidazole-6-carboxylic acid compound and the use thereof, which benzimidazole or azabenzimidazole-6-carboxylic acid compound has a structure as shown in formula (I). The benzimidazole or azabenzimidazole-6-carboxylic acid compound can e...

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Main Authors CAI, XIONG, DENG, XINLAN, LIU, YITING, WU, SHAOBIN, TAN, HUICHEN, LIU, BIN, QING, YUANHUI, FENG, QIAO, FAN, FUSHUN, QIAN, CHANGGENG, LIN, MINGSHENG, WENG, YUNWO, HE, QIJIE
Format Patent
LanguageChinese
English
Published 21.09.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided in the present invention are a benzimidazole or azabenzimidazole-6-carboxylic acid compound and the use thereof, which benzimidazole or azabenzimidazole-6-carboxylic acid compound has a structure as shown in formula (I). The benzimidazole or azabenzimidazole-6-carboxylic acid compound can effectively activate a GLP-1R downstream signal pathway and improve the expression of cAMP, so that the effects of promoting insulin secretion and treating diabetes and complications thereof are achieved, and the benzimidazole or azabenzimidazole-6-carboxylic acid compound has a great application value.
Bibliography:Application Number: TW202211122480