Direct selection of cells expressing high levels of heteromeric proteins using glutamine synthetase intragenic complementation vectors

This invention relates to the general field of recombinant expression of polypeptides in animal cell culture. More specifically, the invention concerns improved selection of cells transfected with recombinantly engineered vectors designed to express polypeptides, in particular heteromultimeric polyp...

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Main Authors MUNRO, TRENT PHILLIP, MCGREW, JEFFREY T, KET, RANDAL ROBERT, AGRAWAL, NEERAJ JAGDISH, DARIS, KRISTINE MARIE, FOMINA YADLIN, DINA A
Format Patent
LanguageChinese
English
Published 11.03.2022
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:This invention relates to the general field of recombinant expression of polypeptides in animal cell culture. More specifically, the invention concerns improved selection of cells transfected with recombinantly engineered vectors designed to express polypeptides, in particular heteromultimeric polypeptides.
Bibliography:Application Number: TW20176115604