A novel il33 form, mutated forms of il33, antibodies, assays and methods of using the same

• Main Authors: STRAIN, MARTIN D, CARMEN, SARA, OVERED-SAYER, CATHERINE L, SCOTT, IAN C, MUSTELIN, TOMAS M, KEMP, BENJAMIN P, REES, DAVID G, LOWE, DAVID C, VOUSDEN, KATHERINE A, HOUSLAY, KIRSTY, COHEN, EMMA S, ENGLAND, ELIZABETH H, SLEEMAN, MATTHEW, BUTLER, ROBIN
• Format: Patent
• Language: Chinese; English
• Published: 21.03.2021
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention provides isolated IL-33 proteins, active fragments thereof and antibodies, antigen binding fragments thereof, against IL-33 proteins. Also provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders.