Methods and compositions for immune protection against extra-intestinal pathogenic e. coli

Compositions and methods are described for inducing an immune response against extra-intestinal pathogenic Escherichia coli (ExPEC) to thereby provide immune protection against diseases associated with ExPEC. In particular, compositions and methods are described for using conjugates of E. coli polys...

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Main Authors ABBANAT, DARREN ROBERT, GAMBILLARA, VERONICA, HAUPTLE, MICHA ANDRES, POOLMAN, JAN THEUNIS, JACQUEMYN, BERT, KOWARIK, MICHAEL THOMAS, KEMMLER, STEFAN JOCHEN, HERMANS, PETER WILHELMUS MARIA, YON, PATRICIA IBARRA, MALLY, MANUELA, WETTER, MICHAEL LUKAS
Format Patent
LanguageChinese
English
Published 11.01.2021
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compositions and methods are described for inducing an immune response against extra-intestinal pathogenic Escherichia coli (ExPEC) to thereby provide immune protection against diseases associated with ExPEC. In particular, compositions and methods are described for using conjugates of E. coli polysaccharide antigens O25B, O1A, 02, and O6A covalently bound to a detoxified exotoxin A of Pseudomonas aeruginosa (EPA) carrier protein as vaccines for the prevention of invasive ExPEC disease caused by ExPEC serotypes O1A, 02, O6A and O25B.
Bibliography:Application Number: TW20165126945