Improved t cell compositions and methods
The present invention provides compositions and methods that downregulate major histocompatibility class I molecule cell surface expression, and uses of such compositions and methods for improving the functional activities of isolated T cells (e.g., gene-modified antigen-specific T cells, such as ch...
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Main Authors | , , |
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Format | Patent |
Language | Chinese English |
Published |
21.05.2020
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention provides compositions and methods that downregulate major histocompatibility class I molecule cell surface expression, and uses of such compositions and methods for improving the functional activities of isolated T cells (e.g., gene-modified antigen-specific T cells, such as chimeric antigen receptor T (CAR-T) cells). In particular, the present invention provides methods and compositions for bolstering the therapeutic efficacy of CAR-T cells. |
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Bibliography: | Application Number: TW20187113023 |