Genetically modified microorganisms for producing long-chain dicarboxylic acid and method of using thereof

Described are genetically-modified microorganisms for producing long-chain dicarboxylic acids and methods of using them. The invention provides a genetically modified microorganism, comprising a first nucleic acid encoding an Umbellularia californica lauroyl ACP- thioesterase (BTE) operably linked t...

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Bibliographic Details
Main Authors HSIEH, HSIN JU, CHIEN, LIANG JUNG, WANG, JIA HUNG, LIN, YU JU
Format Patent
LanguageChinese
English
Published 11.07.2019
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Described are genetically-modified microorganisms for producing long-chain dicarboxylic acids and methods of using them. The invention provides a genetically modified microorganism, comprising a first nucleic acid encoding an Umbellularia californica lauroyl ACP- thioesterase (BTE) operably linked to a promoter and a second nucleic acid encoding a Cocos nucifera lauroyl ACP- thioesterase (FatB3) operably linked to a promoter, wherein the microorganism produces an increased amount of long-chain dicarboxylic acids as compared to the unmodified parent of the microorganism.
Bibliography:Application Number: TW20150121064