High-affinity and aggregation-resistant antibodies based on variable domains vl and vhh-derivatives

The monoclonal IgG-type antibodies comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain V L are offered. The said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibod...

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Main Authors EKIMOVA, VICTORIA MIKHAILOVNA, ULITIN, ANDREY BORISOVICH, EVDOKIMOV, STANISLAV RUDOLFOVICH, GONCHAROVA, OLGA VLADIMIROVNA, CHERNYH, YULIA SERGEEVNA, IVANOV, ROMAN ALEXEEVICH, MOROZOV, DMITRIY VALENTINOVICH, SOFRONOVA, EKATERINA VLADIMIROVNA, KORZHAVIN, DMITRIY VALERIEVICH, NEMANKIN, TIMOTHY ALEKSANDROVICH, USTYUGOV, YAKOV YUREVICH, SOLOVIEV, VALERIY VLADIMIROVICH, CHERNOVSKAYA, TATYANA VENIAMINOVNA
Format Patent
LanguageChinese
English
Published 01.06.2017
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:The monoclonal IgG-type antibodies comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain V L are offered. The said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.
Bibliography:Application Number: TW20154131631