Bicyclic heterocycle compounds and their uses in therapy

The invention relates to bicyclic heterocycle compounds of formula (I):or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositi...

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Main Authors CHESSARI, GIANNI, CHIARPARIN, ELISABETTA, HOWARD, STEVEN, GRIFFITHS-JONES, CHARLOTTE MARY, DAY, JAMES EDWARD HARVEY, JOHNSON, CHRISTOPHER NORBERT, FREDERICKSON, MARTYN, BUCK, ILDIKO MARIA, HEIGHTMAN, THOMAS DANIEL, WOOLFORD, ALISON JO-ANNE, TAMANINI, EMILIANO
Format Patent
LanguageChinese
English
Published 21.11.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to bicyclic heterocycle compounds of formula (I):or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Bibliography:Application Number: TW20121114165