Compounds to fibroblast growth factor receptor-3 (fgfr3) and methods of treatment

The invention provides conjugates that consist of a drug moiety agent and a cell binding agent that target human fibroblast growth factor receptor 3 (FGFR3). These conjugates have therapeutic use as they are designed and tailored to target a specific cell population and deliver a powerful cytotoxin...

Full description

Saved in:
Bibliographic Details
Main Authors EASTMAN, SCOTT W, BALDERES, PAUL J, ERICKSON, HANS K, PLOWMAN, GREGORY D, MOXHAM, CHRISTOPHER M, LUDWIG, DALE L, RIGBY, ALAN C
Format Patent
LanguageChinese
English
Published 11.07.2016
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The invention provides conjugates that consist of a drug moiety agent and a cell binding agent that target human fibroblast growth factor receptor 3 (FGFR3). These conjugates have therapeutic use as they are designed and tailored to target a specific cell population and deliver a powerful cytotoxin inside the cell. The conjugate of the present invention has significant advantages over other conjugates known in the art by providing a targeted tumor therapy as well as bystander activity to neighboring cells in an important oncology receptor that is only moderately expressed.
Bibliography:Application Number: TW20143142504