TWI538688B

• Main Authors: HARADA, MITSUNORI, KATO, YASUKI, OHUCHI, MIHO
• Format: Patent
• Language: Chinese
• Published: 21.06.2016
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention provides a polymer micelle composition capable of stably encapsulating and suitably releasing a drug, and a pharmaceutical composition using the polymer micelle composition. The polymer micelle composition comprises block copolymers each having a hydrophobic polymer chain segment 12 and a hydrophilic polymer chain segment 11. The composition has a structure that a plurality of the block copolymers are arranged radially in a state in which the hydrophobic polymer chain segment 12 is directed inward and the hydrophilic polymer chain segment 11 is directed outward. The composition includes a block copolymer 10 having affinity with HDL 20 as the block copolymers. In the composition, detachment of the block copolymer 10 having affinity with HDL 20 is induced by HDL 20 adhesion attributed to the affinity, then a gap formed through the detachment causes promotion of release of a drug 50 to be encapsulated. The composition allows control of a release speed of the drug to be encapsulated by furth