Heteroaromatic compounds and their use as dopamine d1 ligands

The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated)...

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Main Authors HENDERSON, JACLYN LOUISE, EFREMOV, IVAN VIKTOROVICH, ZHANG, LEI, LEE, CHEWAH, O'NEIL, STEVEN VICTOR, DAVOREN, JENNIFER ELIZABETH, GREEN, MICHAEL ERIC, BRODNEY, MICHAEL AARON, GRAY, DAVID LAWRENCE FIRMAN, MENTE, SCOT RICHARD, ROGERS, BRUCE NELSEN, DOUNAY, AMY BETH
Format Patent
LanguageChinese
English
Published 21.11.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating D1-mediated (or D1-associated) disorders including, e.g., schizophrenia (e.g., its cognitive and negative symptoms), cognitive impairment (e.g., cognitive impairment associated with schizophrenia, AD, PD, or pharmacotherapy therapy), age-related cognitive decline, dementia, and Parkinson's disease.
Bibliography:Application Number: TW20143121727