Use of 10-[(3r)-1-azabicyclo [2,2,2] oct-3-ylmethyl]-10h-phenothiazine for the preparation of a medication exerting a selective inhibition of the m1, m2 and m3 muscarinic receptors

Use of 10-[(3R)-1-azabicyclo[2.2.2]oct-3-ylmethyl]-10H-phenothiazine (I) and its salts for the manufacture of a medicament to prevent or treat disorders, diseases and/or pathologies by selectively inhibiting of muscarinic M1 receptor, muscarinic M2 receptor and muscarinic M3 receptor, is claimed. AC...

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Bibliographic Details
Main Authors CLERC, THIERRY, TISNE-VERSAILLES, JACKY, PRZYBYLSKI, CHRISTOPHE
Format Patent
LanguageChinese
English
Published 21.01.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Use of 10-[(3R)-1-azabicyclo[2.2.2]oct-3-ylmethyl]-10H-phenothiazine (I) and its salts for the manufacture of a medicament to prevent or treat disorders, diseases and/or pathologies by selectively inhibiting of muscarinic M1 receptor, muscarinic M2 receptor and muscarinic M3 receptor, is claimed. ACTIVITY : Uropathic; Antibacterial; Fungicide. MECHANISM OF ACTION : Muscarinic M1 receptor inhibitor; Muscarinic M2 receptor inhibitor; Muscarinic M3 receptor inhibitor. The effect of (I) to inhibit the muscarinic M1 receptor was tested in Chinese hamster ovary cells using in vitro assay. The results showed that (I) exhibited an IC 5 0 value of 1.6 nM.
Bibliography:Application Number: TW200796147644