Process for preparing the antiviral agent [1s-(1 alpha, 3 alpha, 4 beta) ]-2-amino-1, 9-dihydro-9- [4-hydroxy-3-(hydroxymethyl) -2-methylenecyclopentyl] -6h-purin-6-one

The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents comprising: (a) adsorbing the diluted mixture onto a hydrophob...

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Main Authors CHAN, YEUNG Y, PENDRI, YADAGIRI, KUCERA, DAVID J, THOTTATHIL, JOHN K, BIEN, JEFFREY T, SHI, ZHONGPING, CHEN, CHUNG-PIN, SINGH, AMBARISH, BANERJEE, AMIT, STOJANOVIC, MILAN, VEMISHETTI, PURUSHOTHAM, PATEL, RAMESH N, RIJHWANI, SUSHIL K, POWERS, GERALD L, LIANG, JING, LEWIS, CHARLES, KRISHNAMURTY, DHILEEPKUMAR, PRASAD, SIVA JOSYULA, POLNIASZEK, RICHARD P, PATEL, SUNIL S, ZHOU, MAOTANG X, WANG, SHAOPENG, KRONENTHAL, DAVID R, EVANS, JEFFREY M
Format Patent
LanguageChinese
English
Published 21.07.2010
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents comprising: (a) adsorbing the diluted mixture onto a hydrophobic resin bed; (b) washing the resin bed with water to remove salt; and (c) eluting the entecavir or entecavir intermediate from the resin bed with an organic solvent.
Bibliography:Application Number: TW200392135079