Chemical compounds that activate the alpha subtype of the human peroxisome proliferators activated receptor (hPPAR alpha) and pharmaceutical compositions comprising them for treating hPPAR alpha mediated diseases or conditions

A compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof, wherein X1 represents O or S; R1 and R2 are independently H or C1-3 alkyl or R1 and R2 which are bonded to the same carbon atom may together with the carbon atom to which they are bonded form a...

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Bibliographic Details
Main Author GELLIBERT, FRANCOISE JEANNE
Format Patent
LanguageEnglish
Published 21.12.2005
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof, wherein X1 represents O or S; R1 and R2 are independently H or C1-3 alkyl or R1 and R2 which are bonded to the same carbon atom may together with the carbon atom to which they are bonded form a 3-5 membered cycloalkyl ring; R3 and R4 independently represent H, halogen, -CH3 and -OCH3; R5 represents H or C1-6 alkyl; X2 represents NH, NCH3 or O; one of Y and Z is N, and the other is O or S; R6 represents phenyl or pyridyl (wherein the N is in position 2 or 3) and is optionally substituted by one or more halogen, CF3, C1-6 straight or branched alkyl (optionally substituted by halogen), with the provision that when R6 is pyridyl, the N is unsubstituted.
Bibliography:Application Number: TW200291111392