A pharmaceutical composition for fixed-dose association of an angiotensin-converting enzyme inhibitor and of a calcium channel antagonist, method for preparation and a pharmaceutical composition for the treatment of cardiovascular illnesses

• Main Authors: DELGADILLO, DUARTE JOAGUIN, MICHETO ESCUDER, LUIS MANUEL, CANOVAS, PEDRO SOLER
• Format: Patent
• Language: English
• Published: 21.11.2003
• Edition: 7
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Use of said association for the manufacture of a medicament for the treatment of illnesses of the cardiovascular system comprises a dose of (a) enalapril or a pharmaceutically acceptable salt thereof and another dose of (b) nitrendipine or a pharmaceutically acceptable salt thereof and in that it is administered in single-dose gallenic form. The method comprises: (a) dissolving enalapril maleate in water with an inorganic salt; (b) mixing the micronized nitrendipine with a fraction of the disintegrating excipients, the wetting agent, the fragmentary diluting agent, the agglutinating agent, and the plastic diluting agent, previously sieved; (c) granulating the products homogenized in section (b) with the solution obtained in section (a); (d) drying the granulated mass; (e) incorporating the lubricating agent, and the remaining fraction of the disintegrating excipients and homogenizing the calibrated granulate; (f) compressing the granulate.