A pharmaceutical composition for fixed-dose association of an angiotensin-converting enzyme inhibitor and of a calcium channel antagonist, method for preparation and a pharmaceutical composition for the treatment of cardiovascular illnesses
Use of said association for the manufacture of a medicament for the treatment of illnesses of the cardiovascular system comprises a dose of (a) enalapril or a pharmaceutically acceptable salt thereof and another dose of (b) nitrendipine or a pharmaceutically acceptable salt thereof and in that it is...
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Main Authors | , , |
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Format | Patent |
Language | English |
Published |
21.11.2003
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Summary: | Use of said association for the manufacture of a medicament for the treatment of illnesses of the cardiovascular system comprises a dose of (a) enalapril or a pharmaceutically acceptable salt thereof and another dose of (b) nitrendipine or a pharmaceutically acceptable salt thereof and in that it is administered in single-dose gallenic form. The method comprises: (a) dissolving enalapril maleate in water with an inorganic salt; (b) mixing the micronized nitrendipine with a fraction of the disintegrating excipients, the wetting agent, the fragmentary diluting agent, the agglutinating agent, and the plastic diluting agent, previously sieved; (c) granulating the products homogenized in section (b) with the solution obtained in section (a); (d) drying the granulated mass; (e) incorporating the lubricating agent, and the remaining fraction of the disintegrating excipients and homogenizing the calibrated granulate; (f) compressing the granulate. |
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Bibliography: | Application Number: TW199887107210 |