Process for the preparation of ortho-alkylated brnzoic acid derivatives

The invention relates to a process for the preparation of ortho-alkylated benzoic acid derivatives of the formula I, characterized in that an aryl bromide of the formula II is reacted with a secondary or tertiary organolithium compound and CO2. Process for the preparation of ortho-alkylated benzoic...

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Bibliographic Details
Main Authors BARTMANN, EKKEHARD, STEIN, INGEBORG
Format Patent
LanguageEnglish
Published 11.08.2003
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to a process for the preparation of ortho-alkylated benzoic acid derivatives of the formula I, characterized in that an aryl bromide of the formula II is reacted with a secondary or tertiary organolithium compound and CO2. Process for the preparation of ortho-alkylated benzoic acid derivatives of the formula I, in which A is an alkyl radical having from 1 to 4 carbon atoms, characterized in that an aryl bromide of the formula II, in which A is as defined in formula I, is reacted with a secondary or tertiary organolithium compound and CO2, wherein the secondary organolithium compound is chosen from the group consisting of sec-butyllithium, isoprpyllithium, sec-amyllithium, 4-heptyllithium, cyclopropyllithium and cyclohexyllithium and the tertiary organolithium compound is tert-butyllithium.
Bibliography:Application Number: TW199988112363