Novel 7-aryl-6(Z)-heptatrienoic acid retinamides

Compounds of the formula I, wherein R1 and R2 are independently hydrogen, halogen, C1-4alkyl, C1-4alkoxy, or trihalomethy; R3 is hydrogen or C1-4alkyl; and R4 is hydrogen except when R3 is C1-4alkyl then R4 may be C1-4alkyl; R5, R6, R7, R8 and R9 are hydrogen. The said compounds possess apoptotic ac...

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Bibliographic Details
Main Authors FOLEY, LOUISE HELEN, FERGUSON, STEPHEN B, LOVEY, ALLEN J, CHEUNG, ADRIAN WAI-HING
Format Patent
LanguageEnglish
Published 21.09.2001
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of the formula I, wherein R1 and R2 are independently hydrogen, halogen, C1-4alkyl, C1-4alkoxy, or trihalomethy; R3 is hydrogen or C1-4alkyl; and R4 is hydrogen except when R3 is C1-4alkyl then R4 may be C1-4alkyl; R5, R6, R7, R8 and R9 are hydrogen. The said compounds possess apoptotic activity and are useful for the prevention and treatment of cancer.
Bibliography:Application Number: TW199988122200