Inhibitors of solute carrier family 6A member 19 (SLC6A19) and methods of use thereof

Provided herein are compounds of formula (II):, or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein m, n, R2, R3, R5, R6, R7, R8, R9, R10, R11a, R11b, and X are as defined elsewhere herein. Also provided herein are methods of preparing compou...

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Main Authors PITZEN, JENNIFER, TZITZILONIS, CHRISTOS, COOPER, NICOLE, WAHLERS, JESSICA, LEE, PATRICK SANG TAE, ZIEBENHAUS, CHRIS, SCHAMMEL, ALEXANDER WAYNE, LIU, YU-XI, MELLEM, KEVIN, SINZ, CHRISTOPHER JOSEPH, MORGANS, DAVID JOHN JR, REID, ADAM NEIL, DE LA HIGUERA MACIAS, MAXIMILIANO, FASTMAN, NATHAN, KARMEL, CALEB HENRY
Format Patent
LanguageChinese
English
Published 16.08.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are compounds of formula (II):, or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein m, n, R2, R3, R5, R6, R7, R8, R9, R10, R11a, R11b, and X are as defined elsewhere herein. Also provided herein are methods of preparing compounds of formula (II). Also provided herein are methods of inhibiting SLC6A19 and methods of treating a SLC6A19-mediated disease, disorder, or condition in an individual in need thereof.
Bibliography:Application Number: TW20230139033