Nucleic acids for inhibiting expression of AGT in a cell

The invention relates to double-stranded nucleic acid molecules that interfere with or inhibit angiotensinogen (AGT) gene expression. It further relates to therapeutic uses of such inhibition such as for the treatment of AGT-mediated diseases, disorders or syndromes, such as hypertension, pregnancy-...

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Bibliographic Details
Main Authors MORRISON, ELIOT, JOHANNSSEN, TIMO, DAMES, SIBYLLE, CZAJKOWSKI, MACIEJ
Format Patent
LanguageChinese
English
Published 16.03.2024
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:The invention relates to double-stranded nucleic acid molecules that interfere with or inhibit angiotensinogen (AGT) gene expression. It further relates to therapeutic uses of such inhibition such as for the treatment of AGT-mediated diseases, disorders or syndromes, such as hypertension, pregnancy-associated hypertension, borderline hypertension, diabetic hypertension, resistant hypertension, primary hypertension, secondary hypertension, chronic heart failure, stroke, non-alcoholic steatohepatitis (NASH), and/or non-alcoholic fatty liver disease (NAFLD).
Bibliography:Application Number: TW202312126345