Anti-ROR1 antibodies and antibody conjugates, compositions comprising anti-ROR1 antibodies or antibody conjugates, and methods of making and using anti-ROR1 antibodies and antibody conjugates

The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including phar...

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Main Authors BAJJURI, KRISHNA, KIEFEL, HELENA, HANSON, JEFFREY, GAKHAL, AMANDEEP, ABRAHAMS, CRISTINA, MADERNA, ANDREAS, YAM, ALICE, STAFFORD, RYAN, YIN, GANG, LI, XIAOFAN, BEDARD, KRISTIN, YU, ABIGAIL, CALARESE, DANIEL, WEN, MIAO
Format Patent
LanguageChinese
English
Published 01.03.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.
Bibliography:Application Number: TW202312124616