Antibody-drug conjugates of antineoplastic compounds and methods of use thereof
Antibody-drug conjugates that bind to human oncology targets are disclosed. The antibody-drug conjugates comprise an antibody or an antigen-binding fragment thereof covalently linked to at least one BH3 mimetic through a dual linker. The disclosure further relates to methods and compositions for use...
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Main Authors | , , , , , , , , , , , , , , , , , , , |
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Format | Patent |
Language | Chinese English |
Published |
01.03.2024
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Subjects | |
Online Access | Get full text |
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Summary: | Antibody-drug conjugates that bind to human oncology targets are disclosed. The antibody-drug conjugates comprise an antibody or an antigen-binding fragment thereof covalently linked to at least one BH3 mimetic through a dual linker. The disclosure further relates to methods and compositions for use in the treatment of cancers by administering the antibody-drug conjugates provided herein. Linker-drug conjugates comprising at least one BH3 mimetic and methods of making the same are also disclosed. |
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Bibliography: | Application Number: TW202312118818 |