IKAROS Zinc Finger Family degraders and uses thereof

The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of disea...

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Main Authors CHEN, CHEN, CODELLI, JULIAN A, TUDESCO, MICHAEL T, YEUNG, SUET C, SADDIER AXE, DOROTHEE, WATKINS, WILLIAM J, BALAN, GAYATRI, DU, ZHIMIN, SCHWARZWALDER, GREGG M, KIM, MUSONG, VENKATARAMANI, CHANDRASEKAR, THOMAS-TRAN, RHIANNON, WEIST, BRIAN M, BLOMGREN, PETER A, YU, HELEN
Format Patent
LanguageChinese
English
Published 01.12.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.
Bibliography:Application Number: TW20230109625